ABSTRACT
Objective: To compare the central corneal thickness [CCT] in pseudoexfoliation glaucoma [PXG] patients with healthy adults
Study Design: Cross-sectional comparative study
Place and Duration of Study: Armed Forces Institute of Ophthalmology Rawalpindi, from Dec 2009 to Feb 2011
Material and Methods: 30 patients having PXG [Group A] and 30 healthy adults having normal intraocular pressure [Group B] were included in the study. Intraocular pressure [IOP] in both groups was measured using gauged Goldmann applanation tonometer [GAT].Central corneal thickness [CCT] was measured with an ultrasonic pachymeter
Results: The comparison of Mean CCT in both Groups showed that Mean CCT was significantly lesser [17-value <0.05] in PXG Group [519.73 tim] as compared to healthy adults Group [567.48 fim]
Conclusion: CCT in PXG patients group was found to be statistically significantly thinner as compared to healthy adults Group. CCT must be assessed in patients with pseudoexfoliation syndrome [PXF] in order to avoid the underestimation of IOP
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Endothelium, Corneal , Intraocular Pressure , Cross-Sectional Studies , Exfoliation Syndrome , Corneal PachymetryABSTRACT
Background: Rise in intraoccular pressure [IOP] may have significant effects on optic disc
Objective: To compare postmydriasis rise in intraoccular pressure with tropicamide in normal individuals and glaucoma cases with or without rapid progression
Subjects and Methods: Study design: Quasi-experimental. Sampling Technique: Non-Randomized, consecutive sampling. This study was performed on 116 eyes of 116 patients reporting at Eye Department, Combined Military Hospital [CMH], Lahore from 1[st] August 2012 to 30[th] April 2013. They were assigned to three groups based on their glaucoma profile: Group A: Normal subjects without raised IOP or glaucomatous visual field loss. Group B: Diagnosed cases of glaucoma without significant visual field defect progression. Group C: Diagnosed cases of glaucoma with significant visual field defect progression over last two years. SPSS version 16 Software was used for statistical analysis to compare intra-ocular pressure changes postmydriasis in the three groups
Results: IOP rise post-mydriasis was low [1.89 mmhg] in normal individuals whereas the spike was statistically significant in glaucoma patients [5.88 mmHg]. Diagnosed cases of glaucoma with worst prognosis has a relatively higher IOP spike [10.6 mmhg] as compared to those with slower visual field defects [5.88 mmhg] progression.[p<0.05]
Conclusion: Our study showed a significant rise in IOP in glaucoma patients with and without rapid progression as compared to normal subjects. Post-mydriasis IOP spike is a reliable diagnostic and prognostic provocative test for glaucoma suspects and diagnosed cases. However, the negative effects of raised IOP on an already compromised optic nerve head must be kept in mind
ABSTRACT
To compare the intraocular pressure [IOP] lowering effect of topical drug combination [Latanoprost and Timolol] with Latanoprost alone in patients of Primary Open Angle Glaucoma [POAG]. Randomized controlled Trials [RCT]. Armed Forces Institute of Ophthalmology [AFIO] Rawalpindi from December 2009 to May 2011. A total of 240 eyes of 120 patients [68 males and 52 females] were included in the study. The patients were randomized into two groups of 60 each using random numbers table. Group A [60 patients, 12Q eyes] were put on topical drug combination of Latanoprost and Timolol eye drops and Group B [60 patients, 120 eyes] were treated with topical Latanoprost eye drops alone. IOP assessments were done at baseline, 2 weeks, 4 weeks and 8 weeks intervals after initiation of treatment. Both the groups were age matched with mean age in Group A was 56.39 +/- 8.50 years and in Group B was 55.61 +/- 8.95 years [p=0.09]. Both groups showed significant IOP decrease from the baseline at each follow up interval. However after 8 weeks of start of treatment, pressure lowering effect in group A [14.73 +/- 2.50 mmHg] was significantly more as compared to Group B [9.10 +/- 2.51 mmHg] [p<0.001]. Combination therapy of Latanoprost and Timolol is more effective as compared to monoyherapy with Latanoprost in lowering IOP of patients with POAG